Hyaluronic acid is present in almost all tissues and biological fluids. It is a nearly ubiquitous compound, although its presence is larger in the extracellular matrix of soft connective tissue.

Almost half of hyaluronic acid in the human body is formed in the skin, being most of it located in the intercellular space. It can also be found in the cartilage or in the synovial fluid.

With aging, hyaluronic acid concentrations are decreasing progressively generating less elastic and less turgid skin, which justifies its use as an active ingredient in anti- aging cosmetics.